慢性病学杂志2023,Vol.24Issue(12) :1776-1779.DOI:10.16440/J.CNKI.1674-8166.2023.12.04

慢性射血分数降低性心力衰竭合并2型糖尿病患者服用恩格列净的有效性

Efficacy study of engeletin in patients with chronic reduced ejection fraction heart failure combined with type 2 diabetes mellitus

黄金贤
慢性病学杂志2023,Vol.24Issue(12) :1776-1779.DOI:10.16440/J.CNKI.1674-8166.2023.12.04

慢性射血分数降低性心力衰竭合并2型糖尿病患者服用恩格列净的有效性

Efficacy study of engeletin in patients with chronic reduced ejection fraction heart failure combined with type 2 diabetes mellitus

黄金贤1
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作者信息

  • 1. 中山市黄圃人民医院临床药学科,广东 528400
  • 折叠

摘要

目的 分析恩格列净对慢性射血分数降低性心力衰竭(heart failure with reduced ejection fraction,HFrEF)合并2型糖尿病(type 2 diabetes mellitus,T2DM)患者的临床疗效.方法 回顾性分析2020年6月至2022年12月于中山市黄圃人民医院心血管内科和内分泌科100例T2DM合并射血分数降低的慢性心力衰竭患者的临床资料,患者均服用恩格列净片10 mg/d,同时服用纳入研究前的其他药物,观察患者治疗前、3个月及6个月的心功能指标和实验室指标.结果 慢性HFrEF合并T2DM患者接受恩格列净治疗3个月比治疗前心功能以及实验室指标得到改善(P<0.05),且治疗6个月比治疗3个月改善更明显(P<0.05).结论 慢性HFrEF合并T2DM患者服用恩格列净后增强心功能,改善实验室指标,证实了恩格列净治疗该疾病的有效性.

Abstract

Objective To analyze the clinical efficacy of empagliflozin in patients with chronic heart failure with reduced ejection fraction(HFrEF)combined with type 2 diabetes mellitus(T2DM).Methods A total of 100 patients with chronic heart failure with type 2 diabetes mellitus and reduced ejection fraction were retrospectively collected from June 2020 to December 2022 in the Department of Cardiovascular Medi-cine,Zhongshan Huangpu People's Hospital.All patients took 10 mg/d of empagliflozin tablets and took other drugs before the sample was included.The cardiac function indexes and laboratory indexes of the pa-tients before the test,3 months and 6 months were observed.Results The cardiac function and laboratory indexes of patients with chronic HFrEF combined with T2DM were improved after 3 months of treatment with empagliflozin(P<0.05),and the improvement was more obvious after 6 months of treatment than after 3 months of treatment(P<0.05).Conclusion Patients with chronic HFrEF combined with T2DM were treated with empagliflozin to enhance cardiac function and improve laboratory indicators,which confirmed the efficacy and of empagliflozin in the treatment of the disease.

关键词

2型糖尿病/慢性射血分数降低性心力衰竭/心功能/三酰甘油

Key words

Type 2 diabetes mellitus/Chronic heart failure with reduced ejection fraction/Cardiac function/Triac-ylglycerol

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基金项目

中山市医学科研项目(2020A020455)

出版年

2023
慢性病学杂志

慢性病学杂志

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参考文献量18
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