Clinical effect of recombinant bovine basic fibroblast growth factor and compound skin on repairing skin and soft tissues defects on functional regions in diabetics
Objective To investigate the effect of recombinant bovine basic fibroblast growth factor(rb-bF-GF)+compound skin(thick skin+dermal stent)in repairing skin and soft tissue defects in diabetic pa-tients.Methods A total of 60 cases of skin defects in diabetic functional sites caused by different causes were collected from February 2019 to February 2022,and were divided into experimental group(n=30)and control group(n=30)according to different treatment options,and the experimental group was repaired by recombinant bovine alkaline fibroblast growth factor(rb-bFGF)+compound skin(blade thick skin+dermal stent),and the control group was repaired by medium thick skin sheet.The survival rate,wound healing time and number of surgeries were counted for 14 days after surgery,and follow-up was conducted 1,3 and 6 months after surgery to observe whether skin breaks occurred during the 6-month postoperative follow-up period to evaluate patient satisfaction.The t-test and χ2 test were performed on the data.Results Compared with the control group[(79.2±9.4)%],the survival rate of skin flakes in the experimental group[(95.1±6.3)%]was significantly higher(P<0.01),and the wound healing time and number of oper-ations were better than those in the control group(P<0.05),and the satisfaction rate of the experimental group(93.3%)was significantly higher than that of the control group(60.0%)6 months after surgery,which was statistically significant(χ2=10.25,P=0.01).Conclusion Recombinant bovine alkaline fibroblast growth factor+composite skin may obtain good clinical results in the repair of diabetic skin defect wounds,which is worthy of clinical promotion.
DiabeticAcellular dermisWound repairSkin and soft tissue defectClinical effects
万方数据
维普
