Margaret Atwood,queen of Canadian literature,often explores the spiritual world of human beings in her works.For the sake of interpreting the spiritual crisis of individuals,R.D.Laing's The Divided Self offers different horizons of inquiry.Based on Laing's existential psychological analysis,this paper,in terms of individu-als'relationships with others,society and the world,expounds the mentalities of protagonists in Atwood's master-pieces The Edible Woman,The Handmaid's Tale,and Oryx and Crake,respectively,analyzing why they lose themselves in the borderland between sanity and insanity,how they adopt schizophrenic strategies to protect them-selves so as to escape from the real world,and finally what they think about life and death and what decision they make between them.Either in the identity anxiety arising from Canadian national consciousness in her early works,the exploration and prediction of the existence of human society in her middle works,or in the deep concern for the future of mankind and the destiny of the world in her late works,Atwood,through the process of her protago-nists'self-loss,insanity and accumulation,reveals her worries about Canadian people's lack of national conscious-ness,her insights into penetration and infiltration by power politics into the social system of human society in the context of globalization,and her humanistic concern for the future of human beings under the influence of science and technology in the post-human era.