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DPP-4在炎症性肠病中的研究进展

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炎症性肠病(inflammatory bowel disease,IBD)是原因不明的胃肠道慢性炎症状态.二肽基肽酶-4(dipeptidyl peptidase Ⅳ,DPP-4)是一种在免疫细胞和组织细胞表面表达的抗原酶,具有多种功能.本文综述了DPP-4的生物学特性以及其在IBD的诊断和治疗中的研究进展,同时探讨了DPP-4在IBD中的作用机制,以期为进一步深入理解DPP-4在IBD中的作用提供参考.
Research progress of DPP-4 in inflammatory bowel disease
The fundamental pathogenic mechanisms of inflammatory bowel disease(IBD),a chronic inflammatory illness affecting the gastrointestinal tract,are still not fully understood.Dipeptidyl peptidase Ⅳ(DPP-4)is a glycoprotein found on the cell surface that has signaling and enzymatic properties.In addition,there is growing evidence from animal models and clinical trials that DPP-4 inhibitors have potential impacts beyond only lowering blood sugar levels,such as immunomodulatory and anti-inflammatory capabilities.This article reviews the biological properties of DPP-4 and its research progress in the diagnosis and treatment of IBD.It also discusses the mechanism of DPP-4 in IBD,aiming to provide a more in-depth understanding of the role of DPP-4 in IBD.

Inflammatory bowel diseaseDipeptidyl peptidase ⅣDPP-4 inhibitorImmunoregulation

王一然、贺子轩、范茹玉、周施锦、叶宣宣、吴聪

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200093,上海理工大学健康科学与工程学院

200433 上海,海军军医大学第一附属医院临床研究中心

200433 上海,海军军医大学第一附属医院消化内科

炎症性肠病 二肽基肽酶-4 二肽基肽酶-4抑制剂 免疫调节

海军军医大学"远航"军事医学人才项目国防科技项目管理中心基础加强计划技术领域基金

2019-YH-092019-JCJQ-JJ-066

2024

免疫学杂志
第三军医大学,中国免疫学会

免疫学杂志

CSTPCD
影响因子:0.704
ISSN:1000-8861
年,卷(期):2024.40(4)