首页|内质网应激在部分妇科疾病中作用的研究进展

内质网应激在部分妇科疾病中作用的研究进展

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妇科疾病是威胁女性生殖健康的重要因素之一.内质网应激(endoplasmic reticulum stress,ER stress)是女性机体处于疾病状态时因未折叠或错误折叠蛋白在内质网(endoplasmic reticulum,ER)腔上累积而诱发的应激反应,且应激程度不同对女性生殖系统的影响及女性患病风险的增加程度会有较大的差别.有研究表明,ER stress与妇科疾病的发生和发展存在密切关系.本文根据近年来国内外的有关研究报道,对ER stress在几种常见妇科疾病中的作用进行了归纳和概括,以期为妇科疾病的预防、诊断和治疗提供新的研究思路.
Research progress on the role of endoplasmic reticulum stress in gynaecological diseases
Gynecological diseases are one of the important factors that threaten women's reproductive health.Endoplasmic reticulum(ER)stress is a stress response induced by the accumulation of unfolded or misfolded proteins in ER cavity when the female body is in a disease state,and the effects of different stress levels on the female reproductive system and the increase in the risk of female disease will vary greatly.Studies have shown that ER stress is closely related to the occurrence and development of gynecological diseases.Based on the relevant research reports at home and abroad in recent years,this paper summarizes the role of ER stress in several common gynecological diseases to provide new research ideas for preventing,diagnosing,and treating gynecological diseases.

Endoplasmic reticulum stressGynaecological diseasesUnfolded protein responseResearch progress

黄焮榆、阮莲、王妍、苏春宇、苏梦容、郎雯、吕其壮

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537000,玉林师范学院智慧农业学院

537000 玉林,广西农产资源化学与生物技术重点实验室

内质网应激 妇科疾病 未折叠蛋白反应 研究进展

国家自然科学基金玉林师范学院大学生创新创业训练计划

31860708202410606041

2024

免疫学杂志
第三军医大学,中国免疫学会

免疫学杂志

CSTPCD
影响因子:0.704
ISSN:1000-8861
年,卷(期):2024.40(4)