The relationship of NLR,25-(OH)D3 and periostin levels with immune function in children with Henoch-Sch?nlein purpura and their prognostic value
To explore the relationship of neutrophil/lymphocyte ratio(NLR),25-hydroxyvitamin D3[25-(OH)D3]and periostin levels with immune function in children with Henoch-Schönlein purpura(HSP)and their prognostic value,120 children with HSP admitted to our hospital from January 2021 to June 2023 were selected as observation group,and 120 healthy children underwent physical examination during the same period were included as control group.Corresponding methods were used to detect the levels of NLR,serum 25-(OH)D3,periostin and peripheral blood lymphocyte subsets(CD3+,CD4+,CD8+,CD19+,CD56+),IgA,IgM,IgG,C3 and C4,and Spearman correlation analysis was used to analyze the correlation among them.After discharge,the children were followed up for 6 months to observe the prognosis and divided into favorable prognosis group and poor prognosis group,and the levels of NLR,25-(OH)D3 and periostin in the two groups were analyzed and compared.The risk factors for poor prognosis in HSP children were analyzed by logistic regression,and ROC curve was drawn to analyze the predictive value of the three indicators for prognosis.Compared with the control group,the NLR and periostin level in observation group were significantly increased,the 25-(OH)D3 level was significantly decreased(t value ranged from 10.604 to 19.332,P＜0.05),the levels of lymphocyte subsets CD3+,CD4+,CD4+/CD8+,CD19+and CD56+were decreased,the levels of CD8+were increased(t value ranged from 9.368 to 23.587,P＜0.05),the levels of IgA and IgG in peripheral blood were increased,while the levels of IgM,C3 and C4 were significantly decreased(t value ranged from 6.376 to 26.048,P＜0.05).Compared with the HSP children in the good prognosis group,poor prognosis group demonstrated significant differences in disease duration,respiratory tract infection,the levels of white blood cells,NLR,25-(OH)D3 and periostin(t values ranged from 3.006 to 10.806,χ2=5.133,P＜0.05),and all were risk factors affecting the prognosis.The AUC value,sensitivity and specificity of NLR,25-(OH)D3 and periostin combination for predicting the prognosis of HSP children were 0.937,91.86%and 76.47%,respectively,which were higher than the prediction efficacy of the above indexes alone(P＜0.05).In conclusion,NLR,25-(OH)D3 and periostin are related to immune function in children with HSP,and NLR,25-(OH)D3 and periostin are independent influencing factors of HSP poor prognosis,thus combination detection of the three indicators has certain predictive value for prognosis of HSP.
Neutrophil to lymphocyte ratio25-hydroxyvitamin D3Periosteal proteinAnaphylactoid purpuraImmune function
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NSTL
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