As an important part of Mao Ze-dong's philosophical thought,Mao Ze-dong's epistemological thought centers on the relationship between knowledge and practice,which corresponds to the concept of"knowledge and action"in ancient Chinese philosophy.In the long-term practice of applying Marxism to guide China's revolution and construction,Mao Ze-dong summarized and refined China's revolutionary experience,critically inherited China's traditional concept of"knowledge and action",and comprehensively expounded his view of"the unity of knowledge and practice".From the perspectives of basic issues of epistemology,epistemology and the CPC's mass line,and the method of investigation and research that promotes the integration of theory and practice,he systematically enriched and developed Marxist epistemology,and greatly promoted the localization of Marxism in China.