·Diabetic retinopathy(DR)is a late-stage peripheral micro-neurovascular complication of chronic hyperglycemia,leading to blood-retinal barrier impairment and retinal dysfunction.Recent studies have found that diabetic neuroretinopathy(DN)may be one of the earliest events in diabetic retinal alterations.The main features include defective electroretinographic responses in newly diagnosed patients,early self-activation of microglia and Müller cells,reduced activity of neurotransmitters(e.g.,DOPA/GABA),and early mitochondrial dysfunction,such as persistent Drp1-Fis1 fission and mtDNA methylation mismatches.Understanding the molecular basis of DN is essential for elucidating its pathogenesis and developing early treatments.This review summarizes pathological changes and mechanisms of retinal function,glial cells,neurotransmitters,mitochondria,and other factors in early diabetes mellitus,in order to provide a theoretical foundation for investigating early DN mechanisms and developing targeted therapies.
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