注意缺陷多动障碍两种亚型脑血流动力学特征研究
Research on cerebral hemodynamic response under verbal fluency task in two subtypes of ADHD children
华玖州 1张洁 2程芳2
作者信息
- 1. 宁波大学 医学部,浙江 宁波 315211;宁波市康宁医院,浙江 宁波 315201
- 2. 宁波市康宁医院,浙江 宁波 315201
- 折叠
摘要
探讨注意缺陷多动障碍(Attention Deficit and Hyperactive Disorder,ADHD)混合型(ADHD-C)及多动-冲动为主型(ADHD-HI)儿童在言语流畅性任务(Verbal Fluency Task,VFT)中脑血流动力学反应特征及差异.通过整合视听持续性操作测试将ADHD患儿区分亚型(33名ADHD-C型及36名ADHD-HI型),之后采用功能近红外光谱成像仪技术(functional Near-Infrared Spectroscopy,fNIRS)测量两组患儿在VFT中前额和左右颞叶血流动力学反应特征,并计算其积分值与重心值.结果发现,在注意力商数上,ADHD-C组得分均低于ADHD-HI组,差异有统计学意义(P＜0.05);两组亚型患儿视觉得分低于听觉得分,差异均有统计学意义(P＜0.05).在VFT测试中,ADHD-C组的左右颞叶积分值较ADHD-HI组降低,差异有统计学意义(P＜0.05);两组亚型患儿左右颞叶的积分值与综合注意商、听觉注意商、视觉注意商均呈显著正相关(P＜0.01).由此可见,ADHD-C与ADHD-HI亚型在完成VFT时的脑左右颞叶的功能存在差异,且注意力受损越重,其血流动力学激活程度越低.
Abstract
To investigate the characteristics and differences of cerebral hemodynamic responses in two subtypes of attention deficit and hyperactivity disorder(ADHD)children,combined subtype(ADHD-C)and hyperactive-impulsiveness subtype(ADHD-HI)under verbal fluency tasks(VFT)was used.Children with ADHD were divided into ADHD-C group(n=33)and ADHD-HI group(n=36)by integrated visual and audio continuous performance test(IVA-CPT).Characteristics of hemodynamic response in the prefrontal cortex and bilateral temporal lobes during VFT were measured by functional near-infrared spectroscopy(fNIRS).Their integral values and barycenter values were calculated.In terms of attention quotient,the attention quotient score of ADHD-C group was significantly lower than that of ADHD-HI group(P＜0.05).Visual scores of all ADHD children were significantly lower than auditory scores(P＜0.05).Integral values of the temporal lobes of ADHD-C type children were significantly lower than that of ADHD-HI type children under VFT test(P＜0.05).When two subtypes of ADHD children were under VFT,integral value of temporal lobes was positively correlated with full-scale attention quotient,auditory attention quotient and visual attention quotient(P＜0.01).The results demonstrated that the more impaired attention in both ADHD-C and ADHD-HI subtypes is accompanied with the lower hemodynamic activation in the temporal lobes during the VET.
关键词
注意力缺陷多动障碍/亚型/注意力特征/言语流畅性任务/功能近红外光谱成像仪技术Key words
attention deficit hyperactivity disorder/subtype/attention characteristics/speech fluency tasks/functional near-infrared spectroscopy引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据