The current study was designed to determine the chronic and refractory intracellular infections caused by pathogenic bacteria.The drug delivery system consisting of ZIF-8(zeolitic imidazolate framework)as a carrier and 9-carboxylfascaplysin as an antibacterial reagent was applied.The prepared material was characterized by XRD,SEM,UV-vis,TGA and FTIR.The delivery system produced higher thermal stability and remained a similar crystalline microstructure as ZIF-8.This delivery system exhibited a pH-responsive property and releases the drug in a controllable fashion under the acidic microenvironment.The preliminary data indicate that the drug delivery system showed the activity against the intracellular infection in a dose-dependent manner and the MRSA(methicillin-resistant Staphylococcus aureus)infection model.Free 9-carboxylfaspcalysin was unable to inhibit the intracellular infection under the same condition.Our results demonstrate that the ZIF-based drug delivery system with pH-responsive feature shows promising potential against the intracellular bacterial infection.
维普
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