Research Progress on the Extraction and Purification Technology of 1-Deoxynojiri Mycin from Mulberry Leaves and its Hypoglycemic Effect
As a kind of medicinal and edible homologous plant with excellent hypoglycemic effect,mulberry leaf is rich in many bioactive components such as alkaloids,flavonoids and polysaccharides.Among them,1-deoxynojiri mycin(DNJ)is one of the main components of mulberry leaf for hypoglycemia.In recent years,the extraction and purification process of DNJ and its hypoglycemic action mechanism have become a research hotspot.At present,DNJ extraction methods mainly include water extraction method,organic solvent extraction method,ultrasonic assisted method,microwave assisted method,etc..However,the relevant extraction and purification parameters are different,and no systematic extraction and purification pro-cess system has been formed to guide industrial production.The currently recognized mechanism of DNJ's hypoglycemic effect is mainly through competitive inhibition of α-glucosidase activity,while some studies have also suggested that DNJ may achieve the hypoglycemia through anti-inflammatory,antioxidant and regulation of intestinal flora,but the mechanism of ac-tion is still unclear.Therefore,this paper focused on reviewing the extraction and purification process and hypoglycemic mech-anism of DNJ,providing technical reference and theoretical support for the extraction industrialization and hypoglycemic effi-cacy of DNJ.
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