Preparation of Pfaffia paniculata and Lycium barbarum leaf oral liquid with Pfaffia paniculata as the main medicine and Lycium barb arum leaf as the auxiliary medicine.The extraction process of Pfaffia paniculata extract and the preparation of oral liquid were determined by one-way and orthogonal tests and their antioxidant properties were investigated.The results showed that the extraction conditions of Pfaffa paniculata extract was 1∶100(g∶mL),pH value of 4.6,composite enzyme dosage of 1.2%,composite enzyme amount ratio of 2∶1(g∶g),enzyme digestion temperature of 40 ℃,and enzyme di-gestion time of 60 min;the optimal formulation of Pfaffia paniculata and Lycium barb arum leaf oral liquid:the amount of the main medicine was 30%,of which the ratio of crude extract of Pfaffia paniculata to the decoction of Lycium barb arum leaf was 1∶1(mL∶mL),sugar addition was 14%,citric acid was 0.08%,xanthan gum was 0.09%;measured total flavonoids content of the oral liquid was 4.17 mg/g,the scavenging rate of ABTS free radicals was 92.1%,and the scavenging rate of DPPH free radicals was 93.1%;the formulation of the oral liquid with a light yellow color,moderately sweet and sour,sweet and bitter aftertaste,cool sense of smell,good stability,and high.It had good stability and high antioxidant property.