Main efficacy analysis of peppermint based on network pharmacology and molecular docking technology
The main effects of peppermint were studied by means of network pharmacology and molecular dock-ing technology.The components and targets of peppermint were selected using TCMSP database,the protein in-teraction network was constructed using String database,the molecular interaction was verified using Sybyl-X 2.0 software,the enrichment analysis was carried out in David database,and the required network diagram was made using Cytoscape 3.9.1 software.Diseases associated with core targets were obtained from the CTD website for analysis.A total of 10 active ingredients and 102 potential targets were screened,including 10 core targets.317 diseases were obtained from the core targets,mainly concentrated in heart-related diseases,diabetes,hy-pertension,liver and kidney related diseases,lymphoma and so on.The enrichment analysis showed that pepper-mint could negatively regulate the process of apoptosis,aging,response to drugs and other biological processes.It acted on macromolecular complex,nucleocytoplasm,cyclin-dependent protein kinase holoenzyme complex and other positions of cells,and could produce the identical protein binding,enzyme binding,protein phospha-tase 2A binding and so on.Peppermint was mainly involved in cancer-related pathway,lipid and atherosclero-sis pathway,PI3K-Akt signaling pathway,etc.The active components of peppermint mainly acted on core tar-gets such as BCL2,BAK1,TP53,and play anti-cancer,anti-atherosclerosis,anti-diabetes and other effects.
万方数据
维普
