Missing data in patient-reported outcomes in clinical studies and its solutions
Objective To explore missing data in patient-reported outcomes(PRO)and the solutions,and to provide references for reducing the impact of missing data in PRO as much as possible.Methods Relevant literatures at home and abroad were searched,and missing data in PRO were summarized from the perspective of causes and influences of data missing,feasible preventive measures,handling of missing data,and standardized reporting.Results Adequate understanding of the causes and serious impacts of missing data,rigorous study design,and standardized implementation procedures can reduce the risk of data missing in PRO.Reasonable processing and analysis of unavoidable missing data and transparent reporting were beneficial to drawing credible conclusions.Conclusion With the continuous development of scientific research,PRO data should be used more rationally and effectively.
patient-reported outcomesmissing datascaleclinical study
万方数据
维普
