摘要
目的 评价并比较不同非药物措施对乳腺癌患者疲乏的干预效果,为临床提供循证依据.方法 系统检索中国知网、万方、维普、中国生物医学文献数据库、PubMed、Medline、Web of Science、Cochrane Library数据库从建库至 2024年 8月关于非药物干预方式对乳腺癌患者疲乏影响的研究.使用Stata 14.0 软件进行网状Meta分析.结果 最终纳入 38项研究,共 12种干预措施,3 901 例乳腺癌患者.研究结果表明,与常规干预相比,抗阻运动联合高强度间歇运动、有氧运动联合高强度间歇运动、认知行为疗法、瑜伽、按摩对乳腺癌患者疲乏具有较好的改善效果(P<0.05).累积排序概率图下面积显示,抗阻运动联合高强度间歇运动是改善乳腺癌患者疲乏的最佳非药物干预方式.结论 抗阻运动联合高强度间歇运动改善乳腺癌患者疲乏的效果最佳,建议临床护理优先考虑,但仍需高质量随机对照试验进行验证.
Abstract
Objective To evaluate and compare the efficacy of different non-drug interventions on cancer-related fatigue in breast cancer patients,and to provide evidence for the formulation of relevant intervention programs.Methods We systematically retrieved randomized controlled trials(RCT)on the effects of non-drug interventions on cancer-related fatigue in breast cancer patients from CNKI,Wanfang Data,VIP,CBM,Medline,PubMed,Web of Science,the Cochrane Library.The retrieval period spanned from the inception to August 2024.Stata14.0 was used for data analysis.Results A total of 38 studies were included,including 12 non-pharmaceutical interventions,involving 3 901 breast cancer patients.The results showed that compared with conventional care,resistance and high-intensity interval training,aerobic and high-intensity interval exercise,cognitive behavioral therapy,yoga and massage had better effects on cancer-related fatigue in breast cancer patients(P<0.05).The area under the cumulative rank probability map showed that resistance and high-intensity interval training was the best non-drug intervention.Conclusion A combination of resistance exercise and high-intensity interval training is the most effective for alleviating fatigue in breast cancer patients,and it is recommended that clinical nursing prioritize this approach.However,a large number of high-quality RCTs are still needed for the verification.
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