Objective To investigate the incidence of thyroid dysfunction in patients with chronic kidney disease and analyze the influencing factors.Methods One hundred and ninety-eight patients with chronic kidney disease who were treated in Chronic Disease Management Department of the First Affiliated Hospital of Hunan Uni-versity of Traditional Chinese Medicine from Apr.2021 to Apr.2022 were selected,including 71 patients with ab-normal thyroid function and 127 patients with normal thyroid function.The differences in TT3,FT3,TT4,FT4,and TSH between patients with abnormal thyroid function and those with normal thyroid function were analyzed.At the same time,the abnormal thyroid function of patients with different clinical characteristics and the influencing fac-tors were analyzed.The intergroup differences were analyzed using t-test or x2-test,and the influencing factors were analyzed using logistic regression analysis.Results In one hundred and ninety-eight patients with chronic kidney disease,thyroid function abnormality occurred in 71 patients(35.86％),including two or more abnormal thyroid function indicators in 35 patients(49.30％).The total triiodothyronine(TT3),free triiodothyronine(FT3),total thyroxine(TT4)and free thyroxine(FT4)in patients with abnormal thyroid function were(1.02±0.29)nmol/mL,(3.03±0.88)pmol/L,(77.93±20.02)nmol/mL and(11.02±1.95)pmol/L respectively,which was significantly lower in patients with normal thyroid function(1.32±0.25)nmol/mL,(4.20±0.92)pmol/L,(93.30±19.28)nmol/mL and(13.54±1.82)pmol/(P＜0.05),while thyroid stimulating hormone(TSH)was(3.14±0.96)mIU/L,which was significantly higher than that in patients with normal thyroid function(1.84±0.89)mIU/L(P＜0.05).The incidence of thyroid dysfunction in female patients was 50.59％(43/85),It was significantly higher than 24.78％(28/113)of male patients(P＜0.05);The incidence of thyroid dysfunction in patients aged 60 years was 49.55％(55/111),It was significantly higher than 18.39％(16/87)of the patients aged＜60 years(P＜0.05);The incidence of thyroid dysfunction in patients with 1-year duration of disease was 71.43％(30/42),It was significantly higher than 25.28％(41/156)of patients with a course of disease＜1 year(P＜0.05);The incidence of thyroid dysfunction in patients with clinical stage G 4 to 5 was 50.62％(41/81),It was significantly higher than 25.64％(30/117)of pa-tients in G1～3 stages(P＜0.05);The incidence of thyroid dysfunction in patients with diabetes was 74.36％(29/39),This was significantly higher than 26.42％(42/159)in patients without diabetes mellitus(P＜0.05).Logistic regression analysis showed that gender,age,course of disease and clinical stage were the influencing factors of thy-roid dysfunction in patients with chronic kidney disease(P＜0.05).Conclusion A high proportion of patients with chronic kidney disease have abnormal thyroid function,which is affected by the patient's sex,age,course of disease and clinical stage,clinical attention should be paid to targeted intervention to prevent the incidence of thy-roid dysfunction in chronic kidney disease population.
万方数据
维普
