To evaluate the predictive value of multimodal ultrasound combined with serum matrix metalloproteinase-9 in the recurrence of breast cancer after breast-conserving surgery
Objective To explore the predictive value of multimodal ultrasound features combined with serum matrix metalloproteinase-9(MMP-9)detection for tumor recurrence of breast cancer after breast-conserving surgery.Methods A total of 194 patients with breast cancer who underwent breast-conserving surgery in Affiliat-ed Hospital of Jining Medical College from Jan.2017 to May.2018 were selected.Routine ultrasound,automated breast volume imaging and contrast-enhanced ultrasound were performed before surgery.Logistic regression equa-tion was used to analyze the risk factors affecting local tumor recurrence after breast-conserving surgery,and ROC curve was drawn to analyze the predictive value of multimodal ultrasound features combined with serum MMP-9 for local tumor recurrence after breast-conserving surgery.Results After 5 years of follow-up,29 out of 194 breast cancer patients who underwent breast-conserving surgery had local recurrence and metastasis.There were no signif-icant differences in tumor diameter,spiculation sign,convergence sign,Alder blood flow grade,enhancement se-quence,pattern and enhancement intensity between the two groups(P＞0.05t=1.48,P=1.451;x2=0.55,P=0.460;x2=0.50,P=0.478;x2=0.60,P=0.439;x2=0.50,P=0.780;x2=0.04,P=0.981;x2=0.13,P=0.716).Logistic regression analysis showed that irregular tumor shape,small calcification,Peripheral radial enhancement,perfusion defect and abnormal elevation of serum MMP-9 were independent risk factors for local recurrence of breast cancer after breast-conserving surgery(P=0.034,95％CI=1.177～62.266;P=0.048,95％CI=1.022～58.397;P=0.045,95％CI=1.100～56.756;P=0.043,95％CI=1.079～60.937;P=0.044,95％CI=1.000～1.026).ROC curve showed that the AUC of multimodal ultrasound features combined with serum MMP-9 in predicting local tumor recurrence after breast-con-serving surgery was 0.970,and the sensitivity and specificity were 98.63％and 91.67％,respectively.Conclusions Multimodal ultrasound features combined with serum MMP-9 detection have high application value in the evalua-tion of local tumor recurrence after breast-conserving surgery,and provide a new idea for the clinical diagnosis and treatment of breast cancer.
Automated breast volume imagingContrast-enhanced ultrasoundMatrix metalloprotein-ase 9Breast cancerBreast-conserving surgery
万方数据
维普
