首页|脱碘同功酶在细胞层面的甲状腺激素水平调控机制与研究现状

脱碘同功酶在细胞层面的甲状腺激素水平调控机制与研究现状

The regulatory mechanism and research status of deiodinating isozymes at the cellular level of thyroid hormone levels

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随着甲状腺彩色多普勒超声被纳入常规体检项目,甲状腺良恶性病变的阳性检出率逐年走高,甲状腺术后患者成为一个越来越庞大的群体,但外源性补充甲状腺激素如何替代缺失甲状腺方面的研究尚不完善.脱碘酶作为甲状腺激素激活和失活的开关,对维稳人体的内环境具有重要作用,这些酶的表达在个体中会随着每个器官的不同需求而出现变化.以往我们在基础医学方面对脱碘酶做出很多详尽描述,但在临床方面的作用原理相对缺失.本文通过查阅文献对脱碘酶的作用机制作一综述,拟探讨脱碘酶在甲状腺术后外源性补充甲状腺激素中的基本原理.
As color doppler ultrasound listed as the thyroid to regular physical examination project,the positive detection rate of benign and malignant thyroid diseases has increased year by year.The population of pa-tients after thyroid surgery is getting larger and larger,however,the research on how to replace the absent thyroid with exogenous thyroid hormone is not perfect.As the switch of thyroid hormone activation and deactivation,deio-dinase plays an important role in maintaining the internal environment of human body.The expression of these en-zymes will change with the different needs of each organ in the individual.In the past,many authors have made a detailed description of deiodinase in basic medicine,but the principle of action in clinical aspects is relatively lack-ing.In this paper,the mechanism of deiodinase was reviewed through literature reading,to explore the basic princi-ple of deiodinase in exogenous thyroid hormone supplementation after thyroid surgery.

ThyroidectomyExogenous thyroid hormone supplementationThyroid hormoneDeio-dinase

何欣、彭颖、彭菁、王士琪、程若川

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昆明医科大学,昆明 650500

昆明医科大学第一附属医院甲状腺疾病诊治中心,昆明 650032

甲状腺术后 外源性补充甲状腺激素 甲状腺激素 脱碘酶

云南省"万人计划"—名医专项

RLCRC20210412

2024

中华内分泌外科杂志
中华医学会

中华内分泌外科杂志

CSTPCD
影响因子:0.657
ISSN:1674-6090
年,卷(期):2024.18(1)
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