The incidence of parathyroid hyperfunction is high and its clinical manifestations are diverse.Some patients develop chest tightness and palpitations as the main discomfort,which may be caused by the hypocal-cemia and hypercalcemia related to negative calcium balance and parathyroid hyperfunction.We report a case of 53 years old male with parathyroid hyperfunction who was diagnosed with osteoporosis before and received conven-tional regular supplementation of vitamin D and calcium supplements.However,his condition worsened and he de-veloped chest tightness and palpitation.After 1 month of sufficient supplementation of calcium,the symptoms of chest tightness and palpitation disappeared completely.Then we continued to provide the patients enough vitamin D and calcium supplementation actively.After 1 year of follow-up,the patient's condition was stable.His discom-fort of chest tightness and palpitation never recurred,and all the bone metabolism indicators returned to normal.