Surgery is the important treatment for each type of thyroid cancer.Single or multiple parathy-roid injuries or blood supply disorders may occur during the operation,resulting in dramatic decline of parathyroid hormone and hypocalcemia after operation,which is common in clinical practice.After discharge,chronic hypocal-cemia can cause great physical and psychological pain to patients.Although the residual parathyroid glands can compensate after surgery in some cases,long-term negative calcium balance and postoperative hypocalcemia may cause excessive hyperplasia of the residual parathyroid glands,resulting in parathyroid hyperfunction or even hy-perparathyroidism,which can lead to osteoporosis,urinary calculi,metastatic vascular calcification,and systemic abnormal migratory calcium deposits.It's advisable to enhance the awareness of the cause and harm of the postop-erative hypocalcemia,evaluate and diagnose it early,and actively intervene in every stage of before,during and af-ter the operation and long-term follow-up,which can effectively reduce the occurrence and severity of hypocalcemia and improve the postoperative life quality and the prognosis.