Objective To investigate the effect of enteral nutrition support on quality of life and therapeu-tic effect in patients with metastatic colorectal cancer.Methods A total of 100 patients with metastatic colorectal cancer admitted to Anqing Petrochemical Hospital from Jan.2020 to Dec.2023 were selected and divided into par-enteral nutrition group and enteral+parenteral nutrition group with 50 cases each using random number table meth-od.The parenteral nutrition group received parenteral nutrition,and the parenteral+parenteral nutrition group was supplemented with enteral nutrition.The therapeutic effect,nutritional indexes,intestinal flora,survival time and quality of life before and after treatment were compared between the two groups.Results The effective rate of en-teral+off-site nutrition group was 76.00％,that of parenteral nutrition group was 54.00％,and that of enteral+off-site nutrition group was higher than that of parenteral nutrition group(P＜0.05).There were no significant differenc-es in nutritional indexes,flora imbalance grade or QLQ-C30 score between the two groups before intervention(P＞0.05).After the intervention,the albumin and total protein in the enteral+parenteral nutrition group were(38.76±6.02)g/L,(64.09±6.71)g/L,the number of normal microbiota disorder cases was 46,the survival time was(17.055±4.33)months,the physical function score was(74.59±7.55)points,and the emotional function score was(78.94±7.96)points,cognitive function score(88.95±9.03)points,role function score(85.49±8.61)points,social function score(81.45±8.27)points.In the parenteral nutrition group,the albumin was(34.51±5.47)g/L,the total protein was(58.91±6.55)g/L,the number of normal microbiota disorder cases was 33,the survival time was(12.48±3.59)months,the physical function score was(67.21±6.81)points,and the emotional function score was(73.55±7.78)points,cognitive function score was(83.47±8.55)points,role function score was(80.14±8.26)points,social function score was(76.93±7.827)points,and enteral+off-site nutrition group was higher than paren-teral nutrition group(P＜0.05).In the enteral+off-site nutrition group,the transferrin was(1.45±0.57)g/L,and there were 2 cases of class Ⅱ flora dysregulation and 2 cases of class Ⅲ flora dysregulation;in the off-site nutrition group,the transferrin was(1.71±0.61)g/L,and the number of class Ⅱ flora dysregulation was 8 cases and the num-ber of class Ⅲ flora dysregulation was 9 cases.Enteral+off-site nutrition group was lower than parenteral nutrition group(P＜0.05).Conclusion Enteral+parenteral nutrition support Enteral nutrition support can help improve the treatment effect of metastatic colorectal cancer,improve the nutritional status and survival time of patients,and improve the quality of life of patients.
Enteral nutritionColorectal cancerNutritionQuality of life
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