摘要
巴豆酰化是一种蛋白质翻译后酰化修饰,虽相关研究主要集中在组蛋白,但越来越多研究发现,非组蛋白的巴豆酰化修饰能参与人体重要生物学功能.本文通过调研近年相关文献,对非组蛋白巴豆酰化修饰的内容进行系统阐述.除巴豆酰化分子调控机制,我们重点阐述了非组蛋白巴豆酰化如何参与调控DNA损伤反应、细胞增殖、肌源性分化、组织纤维化等重要细胞生物学功能.本文旨在通过综述近年来非组蛋白巴豆酰化修饰的生物学意义,为将来非组蛋白的巴豆酰化在临床中的深入研究提供理论基础.
Abstract
Crotonylation is a protein post-translational acylation modification,although mainly focused on histones,but more and more studies have found that non-histone crotonylation modifications can participate in im-portant biological functions of the human body.By investigating the relevant literature in recent years,this paper systematically elaborates the content of non-histone crotonylation modification.Firstly,the regulatory mechanism of crotonylation,that is,the transfer of crotonyl groups on protein lysine regulated by multiple enzyme systems,was elucidated.Secondly,it is described that non-histone proteins with crotonylation can participate in biological pro-cesses such as DNA damage response,cell proliferation,myogenic differentiation,and tissue fibrosis.This article aims to provide a theoretical basis for subsequent non-histone crotonylation research by reviewing the regulation and disease aspects of non-histone crotonylation modification in recent years,and to explore new methods for the clinical prevention and treatment of related diseases.
基金项目
吉林省财政厅项目(2021SCZ23)
吉林省自然科学基金项目(YDZJ202201ZYTS112)
NETL
NSTL
万方数据