Thyroid cancer is the common malignant tumor in the neck,and surgery is the important treat-ment measure for it.Some patients suffer from hypoparathyroidism and hypocalcemia after thyroidectomy,which will seriously affect the patient's life quality and prognosis.This article reported a case of 42 years old female pa-tient with hypocalcemia for 6 years after total thyroidectomy due to thyroid cancer,who still had frequent hypocalce-mia with high dose of oral calcium and active vitamin D supplementation.Long-term and frequent facial and limb numbness,convulsions,epileptic-like seizures and sudden unconsciousness afflicted her due to hypocalcemia.Af-ter admission,her symptoms were obviously relieved after one week of adequate calcium supplementation through oral administration or intravenous infusion under close monitoring.Upon discharge she was able to maintain the normal level of blood calcium by decreased dose of oral calcium supplementation alone.Long-term limb numbness,convulsions,low back pain,shoulder pain,walking instability and other symptoms disappeared basically.The epi-leptic-like seizures did not recur.During six months of follow-up,her blood calcium was still well controlled in nor-mal level.