[Objectives]This experiment was conducted to investigate the effects of wet extruded and fermented soybean meal on growth performance,immune function and amino acid digestibility in weaned piglets.[Methods]A total of 288 piglets weaned at 21 days of age with similar body weight and half male and half female were randomly divided into 4 groups with 6 replicates per group and 12 piglets per replicate.The conventional group(Con)was fed with conventional soybean meal,and 3 experimental groups(WeSM1,WeSM2,FSM)were fed with wet extruded soybean meal(2 groups)and fermented soybean meal respectively.On 14 and 49 days of the trial period,one healthy weaned piglet was randomly selected from each replicate for blood collection.On 47 to 49 days of the experiment,feces were collected for 3 consecutive days to determine nutrient and amino acid digestibility.[Results]The average daily gain and feed intake of weaned piglets in wet extruded soybean meal group 1(WeSM1)and wet extruded soybean meal group 2(WeSM2)were higher than those in conventional soybean meal group(P>0.05).Among them,wet extruded soybean meal group 1 had the best effect.The ratio of feed to gain in fermented soybean meal group was significantly higher than that in conventional soybean meal group(P<0.05).Compared with conventional soybean meal and fermented soybean meal,feeding wet extruded soybean meal could significantly increase the apparent digestibility of gross energy and ash of weaned piglets(P<0.05).Compared with conventional soybean meal group,the apparent digestibility of lysine,arginine,serine and aspartic acid in the other three groups were significantly increased(P<0.05).Among them,wet extruded soybean meal group 1 had the best effect.Compared with conventional soybean meal group,the contents of free arginine,lysine and tyrosine in serum of wet extruded soybean meal group 2 and fermented soybean meal group significantly increased(P<0.05).On the 14th day of the experiment,compared with conventional soybean meal group,serum globulin content in fermented soybean meal group significantly increased,and the ratio of albumin to globulin significantly decreased(P<0.05),fermented soybean meal group and wet extruded soybean meal group 2,the serum IgM content of weaned piglets significantly increased(P<0.05),in wet extruded soybean meal group 1 and 2 and fermented soybean meal group the serum MDA content of piglets significantly increased(P<0.05);compared with wet extruded soybean meal group 1 and wet extruded soybean meal group 2,in fermented soybean meal group,the activity of GSH-Px in serum on 49 days significantly increased(P<0.05).[Conclusions]Wet extruded and fermented soybean meal could improve growth performance,nutrient digestibility,relevant serum antioxidant and immune indexes and free amino acid content of weaned piglets.Fermented soybean meal was superior to wet extruded soybean meal in improving serum antioxidant and immune function,but inferior to wet extruded soybean meal in improving the growth performance and nutrient apparent digestibility of piglets.