The development of multidrug resistance(MDR)in cancer cells during chemotherapy poses a significant challenge in the clinical treatment of breast cancer.One of the main contributors to drug resistance is the robust DNA damage repair capability of tumor cells.The research had revealed that Flap endonuclease 1(FEN1),a core protein involved in the base excision repair(BER)pathway,was highly expressed in adriamycin-resistant breast cancer cells.Moreover,the study found that the FEN1 inhibitor SC13 significantly enhanced the sensitivity of MCF-7/ADR cells to adriamycin.While the precise mechanism of action was not yet fully understood,it was hypothesized that the enhanced sensitivity of MCF-7/ADR cells may be attributed to the activation of potent antitumor responses mediated by the cGAS-STING-NFκB signaling pathways.
关键词
乳腺癌/Flap核酸内切酶1/阿霉素/肿瘤治疗/化疗耐药
Key words
breast cancer/FEN1/adriamycin/tumor treatment/chemoresistance
维普
万方数据