Clinical study on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid enhanced magnetic resonance imaging for assessing liver function in patients with chronic hepatitis B
Objective:To study the performance of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid(Gd-EOB-DTPA)enhanced magnetic resonance imaging(MRI)for assessing liver function in patients with chronic hepatitis B(CHB).Methods:60 patients with CHB were included in this prospective study from Oct.1,2022 to Dec.10,2023.Gd-EOB-DTPA enhanced MRI was conducted,and then the signal intensity ratio(SIR)and con-trast enhancement index(CEI)for each phase were calculated.SIR and CEI were compared with Child-Pugh grad-ing,real-time shear wave elastography(SWE)and non-invasive liver fibrosis models including APRI,FIB-4,GPR.Results:SWE(P＜0.001),SIR(P =0.005)and CEI(P =0.003)in the liver biliary phase(HBP),FIB-4(P＜0.001)showed statistical differences in different Child-Pugh grades.Statistically significant differences were found in SIRHBP(P =0.031),CEIHBP(P =0.001)and FIB-4(P＜0.001)of different SWE levels.SWE showed signifi-cant differencesbetween the low-level CEIHBPand the medium-level CEIHBP(P =0.017)as well as high-level CEIHBP(P =0.022).Child-Pugh levels showed differences among different CEIHBP group(P =0.011).A negative correla-tion was found between CEIHBPand SWE(r =-0.397 3,P =0.001 7).The area under the curve(AUC)of the CEIHBP level for Child Pugh B +C grade was 0.720,the sensitivity and specificity were 0.818 and 0.605,respec-tively.Conclusion:Gd-EOB-DTPA enhanced MRI is an effective method for evaluating liver function in patients with CHB.CEIHBP couldquantitatively measure liver function.
magneticresonance imaginggadolinium ethoxybenzyl diethylenetriamine pentaacetic acidchronic hepatitis Bliver function
NETL
NSTL
万方数据
维普
