首页|115例宫颈鳞癌患者的临床病理特点及治疗后生存分析

115例宫颈鳞癌患者的临床病理特点及治疗后生存分析

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目的:探讨115 例宫颈鳞癌患者的临床病理特点,并进行治疗后生存分析.方法:回顾性分析 2019年1 月至12 月南通市肿瘤医院收治的115 例宫颈鳞癌患者的临床资料,采用SPSS 23.0 软件对数据进行统计学分析,采用Kaplan-Meier生存分析法、Log-rank检验、Cox比例风险回归模型进行生存分析及影响因素分析.结果:115 例宫颈鳞癌患者中,72.17%的肿瘤大小≤4 cm;52.17%的浸润深度>1/2;95.65%的分化程度为中、低分化;22.61%出现淋巴结转移;32.17%出现淋巴脉管浸润;92.17%无神经侵犯;98.26%无宫旁浸润;所有病例均未出现卵巢转移.3 年生存率90.43%,11 例死亡.多因素Cox分析结果显示,宫颈鳞癌患者的3 年总体生存率与浸润深度、分化程度、是否淋巴结转移、是否淋巴脉管浸润有关(P<0.05).结论:115 例宫颈鳞癌中、低分化构成比较高,多数肿瘤大小≤4 cm,可能出现淋巴结转移、淋巴脉管浸润、神经侵犯,经规范治疗后 3 年总体生存率尚可.浸润深度、分化程度、是否淋巴结转移、是否淋巴脉管浸润是影响115 例宫颈鳞癌患者3 年总体生存率的独立因素.
Analysis of clinicopathologic characteristics and survival of 115 cases of cervical squamous cell carcinoma
Objective:To investigate the clinicopathological characteristics of 115 cases of cervical squamous cell carcinoma,and to analyze the survival after treatment.Methods:The data of 115 cases of cervical squamous cell carcinoma admitted to the Nantong Tumor Hospital from January 2019 to December 2019 were analyzed retrospec-tively,SPSS23.0 software was applied for statistical analysis of the data,Kaplan-Meier survival analysis,Log-rank test and Cox proportional risk regression model were used for survival analysis and influencing factors analysis.Results:Among the 115 cases of cervical squamous cell carcinoma,72.17%of patients had tumors≤4 cm in size;52.17%of patients had infiltration depth>1/2;95.65%of patients had moderate to low differentiation;22.61%of patients had lymph node metastasis;32.17%of patients had lymphatic vessel infiltration;92.17%of patients had no nerve invasion;98.26%of patients had no periuterine infiltration;no ovarian metastasis occurred in all cases.The 3-year survival rate was 90.43%,and 11 cases died.Multivariate Cox analysis showed that the 3-year overall survival rate of patients with cervical squamous cell carcinoma was related to the depth of invasion,de-gree of differentiation,lymph node metastasis and lymphatic vessel invasion(P<0.05).Conclusion:Most of the 115 patients with cervical squamous cell carcinoma are of medium to low differentiation,with tumors≤4 cm in size and lymph node metastasis,lymphatic vessel invasion and nerve invasion.After standardized treatment,the 3-year overall survival rate is still acceptable.The depth of invasion,degree of differentiation,lymph node metastasis and lymphatic vessel invasion are independent factors affecting the 3-year overall survival rate of 115 patients with cervi-cal squamous cell carcinoma.

cervical squamous cell carcinomaclinicopathological characteristicssurvival analysis

李咏、张璨、何爱琴、季瑞

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南通市肿瘤医院/南通大学附属肿瘤医院 妇科,江苏 南通 226361

宫颈鳞癌 临床病理特点 生存分析

南通市科技计划项目南通市卫生健康委项目面上课题南通市卫生健康委项目面上课题

JCZ20016MB2020023MS2022045

2024

东南大学学报(医学版)
东南大学

东南大学学报(医学版)

CSTPCD
影响因子:1.374
ISSN:1671-6264
年,卷(期):2024.43(1)
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