Changes and clinical significance of serum ficolin-3 and Angptl4 levels in patients with gestational hypertension
Objective:To investigate the changes and clinical significance of serum levels of ficolin-3 and angio-poietin-like protein 4(Angptl4)in patients with gestational hypertension.Methods:A total of 102 patients with pregnancy induced hypertension who were treated in our hospital from May 2020 to May 2022 were selected as the observation group.According to the patients'condition,they were grouped into hypertension group(37 cases),mild preeclampsia group(42 cases)and severe preeclampsia group(23 cases).Another 102 healthy pregnant women in our hospital were selected as the control group.Serum levels of ficolin-3 and Angptl4 were measured by enzyme-linked immunosorbent assay(ELISA).Pearson correlation was used to analyze the correlation between serum fico-lin-3 and Angptl4;the diagnostic value of serum ficolin-3 and Angptl4 in pregnancy induced hypertension was eval-uated by ROC curve;multivariate Logistic regression was used to analyze the risk factors of pregnancy induced hy-pertension.Results:Compared with the control group,the levels of serum ficolin-3 and Angptl4 in the observation group were obviously lower(P＜0.05).The levels of serum ficolin-3 and Angptl4 in hypertension group,mild pre-eclampsia group and severe preeclampsia group decreased gradually(P＜0.05).Pearson correlation analysis showed that there was a positive correlation between serum ficolin-3 and Angptl4 in the observation group(r = 0.527,P＜0.001).The AUC of combined diagnosis of pregnancy induced hypertension by serum ficolin-3 and An-gptl4 was higher than that of single diagnosis of pregnancy induced hypertension by serum ficolin-3(Z =2.595,P = 0.009)and single diagnosis of pregnancy induced hypertension by serum Angptl4(Z =5.201,P＜0.001).Com-pared with the control group,PLT in the observation group decreased obviously,and MPV,PDW,and PagT in-creased obviously(P＜0.05).Low expression of serum ficolin-3,low expression of Angptl4,low level of PLT,high level of MPV,high level of PDW and high level of PagT were risk factors affecting the occurrence of pregnancy induced hypertension(P＜0.05).Conclusion:The serum levels of ficolin-3 and Angptl4 in patients with gesta-tional hypertension are decreased,which are related to the severity of gestational hypertension.Detection of the changes of ficolin-3 and ANGPTL4 can accurately evaluate gestational hypertension.
pregnancy induced hypertensionficolin-3angiopoietin like protein 4diagnosis
NETL
NSTL
万方数据
维普
