Efficacy and of post-mastectomy radiation therapy on the prognosis of patients with early-stage breast cancer with sentinel lymph node micro-metastasis:a Meta-analysis
Objective:To compare and analyze the prognosis of patients with early stage breast cancer with micro-metastases in the sentinel lymph nodes treated with post-mastectomy radiation therapy(PMRT)after mastectomy and without PMRT.Methods:China Biology Medicine(CBM),China National Knowledge Infrastructure(CNKI),Chi-na Science and Technology Journal Database,Wanfang database,PubMed database,Embase database,Web of sci-ence(WOS)database,and Cochrane library.The screening was independently performed by two researchers ac-cording to the inclusion and exclusion criteria,extracting data,assessing methodological quality,and analyzing re-sults were achieved.Stata17.0 and Review Manager5.4 software were applied for Meta-analysis.Results:A total of nine retrospective studies were included,with a median follow-up of 30 to 98 months.Meta-analysis showed that the PMRT after mastectomy did not significantly improve the breast cancer-specific survival(BCSS)(HR =1.18,95%CI:0.94-1.48,Z =1.43,P =0.15),disease-free survival(DFS)(HR =0.51,95%CI:0.07-3.62,Z =-0.668,P =0.50),and overall survival(OS)(HR =1.02,95%CI:0.93-1.12,Z =0.39,P =0.70)in the early-stage breast cancer with sentinel lymph node micro-metastasis.Conclusion:For patients with early-stage breast cancer and micro-metastases in the sentinel lymph nodes(T0,T1-2NmiM0),PMRT after mastectomy does not improve BCSS,DFS,and OS.
breast neoplasmssentinel lymph node micro-metastasismastectomyradiotherapyMeta-analysis
NETL
NSTL
万方数据
维普
