Relationship between clinicopathological features of gastric cancer and metabolic parameters,heterogeneity index of 18F-FDG PET/CT
Objective:To investigate the relationship between18 F-FDG PET/CT metabolic parameters and hetero-geneity index(HI)and the clinicopathological features of gastric cancer.Methods:The 18 F-FDG PET/CT and clinicopathological data of 74 patients with pathologically confirmed gastric adenocarcinoma were retrospectively ana-lyzed.Maximum standardized uptake value(SUVmax),mean standardized uptake value(SUVmean),tumor met-abolic volume(MTV),total glycolysis volume(TLG),and HI were measured in the primary foci.HI-1 was the co-efficient of variation(CV)of SUV values within the region of interest,and HI-2 was the absolute value of linear re-gression slopes of the MTV values at different SUVmax thresholds.Spearman's rank correlation and Logistic regres-sion analysis were used to assess the correlation between the above parameters and clinicopathologic features of gas-tric cancer.Results:SUV value and HI were significantly different in gastric cancers with different degrees of dif-ferentiation(P＜0.01),and the degree of differentiation was moderately positively correlated with both SUVmax and HI-1(r =0.32,0.39,all P＜0.05).The SUV value and HI-1 were lower in gastric cancers containing low adherent cell components(P＜0.05).TLG≥57.5 g was an independent risk factor for stage Ⅳ gastric cancer[OR:6.089(1.08,34.33)].Conclusion:18 F-FDG PET/CT metabolic parameters and HI reflect clinical and pathological information of some gastric cancers.
18 F-FDGPET/CTdegree of differentiationpoorly cohesive gastric carcinoma
NETL
NSTL
万方数据
维普
