Study on the correlation between zinc nutrition status and sex hormone levels,sexual organ development of precocious girls
Objective:To explore the correlation between zinc nutrition and sex hormone levels,sexual organ de-velopment in girls with precocious puberty,and to provide new ideas for the prevention and treatment of precocious puberty.Methods:A convenient sampling method was used to study 102 cases of central precocious puberty(CPP)(CPP group)and 231 cases of peripheral precocious puberty(PPP)(PPP group)in the pediatric clinic and inpa-tients of Huai'an Clinical College of Xuzhou Medical University from January 2022 to December 2022.In addition,100 healthy children were selected from the child care clinic in the same period as the control group.The general data such as age and body mass index were recorded,and the examination of blood hormone,serum zinc,insulin growth factor-1 and uterine attachment examination were completed.The differences of zinc nutritional status among the three groups of girls were compared,and the correlation between zinc nutritional status and sex hormone level and sexual organ development of precocious girls was analyzed.Results:the levels of serum zinc and urinary zinc in CPP and PPP group were higher than those in control group(P<0.001).In CPP group,the serum zinc level was positively correlated with the levels of follicle-stimulating hormone,prolactin,estradiol,uterine volume and ovarian volume(r:0.52,0.57,0.48,0.52,0.50,P<0.05).Zinc supplementation was correlated with the oc-currence of CPP and PPP(OR:2.286,1.998,P<0.05).Conclusion:Zinc supplementation is common in girls with precocious puberty.The serum and urinary zinc levels are generally high in girls with precocious puberty,and the serum zinc level is positively correlated with the sex hormone level and sexual organ development.
precocious pubertyzincsex hormonesexual organ developmentcorrelationgirl
NETL
NSTL
万方数据
维普
