Predicting the risk of neutropenia after synchronous radiotherapy and chemotherapy for NSCLC
Objective:To explore the value of random forest model in predicting neutropenia in non-small cell lung cancer(NSCLC)after synchronous radiotherapy and chemotherapy,in order to provide reference for early clin-ical prediction of the risk of neutropenia and the development of corresponding intervention measures.Methods:295 NSCLC patients were selected from January 2020 to August 2022 in our hospital,all of whom received synchro-nous radiotherapy and chemotherapy,they were divided into neutropenia group(n =91)and non-neutropenia group(n =204)according to whether neutropenia occurred after chemotherapy,and the random number table method was used to establish the training set and the test set according to the ratio of 2∶ 1,and the random forest model was constructed.The predictive efficacy of random forest model for neutropenia was analyzed by receiver operating char-acteristic(ROC)curve.Results:The differences in age,weight,chemotherapy delay,synchronous regimen dose,concurrent radiotherapy and chemotherapy cycle,enteral nutrition support,hypertension,diabetes mellitus,auto-immune disease,and prophylactic granulocyte colony stimulating factor(G-CSF)application between the two groups were statistically significant(P<0.05).Chemotherapy delay,synchronous radiotherapy and chemotherapy cycle,enteral nutrition support,age,chemotherapy regimen dose,and weight were all factors associated with the develop-ment of neutropenia(P<0.05).The random forest model based on chemotherapy delay,synchronous radiotherapy and chemotherapy cycle,enteral nutrition support,age,chemotherapy regimen dose,and body weight predicted neutropenia with an AUC of 0.857,sensitivity 80.00%,and specificity 95.00%.Conclusion:A random forest model based on chemotherapy delay,synchronous radiotherapy and chemotherapy cycle,enteral nutrition support,age,chemotherapy regimen dose,and body weight has a high predictive value for assessing neutropenia after syn-chronous radiotherapy and chemotherapy in patients with NSCLC,and these factors can be used to develop a targe-ted intervention plan to reduce the risk of neutropenia in the clinic.
NETL
NSTL
万方数据
维普
