Constructing a Nomogram diagnostic model for nephroblastoma in children based on ultrasonography and tumor cytokines
Objective:To construct a Nomogram diagnostic model for nephroblastoma in children based on ultra-sonography and tumor cytokines,so as to improve the clinical diagnostic efficiency of nephroblastoma.Methods:A total of 82 children with nephroblastoma admitted to our hospital from January 2019 to January 2023 were selected as the study group,and another 82 children with cystic nephropathy during the same period were selected as the con-trol group,which were confirmed by surgery pathological results.The ultrasonography was performed before surger-y.The ultrasonic characteristics and clinical data of the two groups were compared,and the influencing factors of the occurrence of nephroblastoma were analyzed by Logistic analysis.A Nomogram diagnostic model for nephroblas-toma based on the influencing factors was constructed,and the Nomogram diagnostic model was verified by receiver operating characteristic(ROC)curve and calibration curve.Results:There were significant differences in mass na-ture,internal echo,adjacent structures invasion and metastasis,inferior vena cava thrombosis,accompanying ipsi-lateral renal vein thrombosis,arterial peak velocity,blood flow resistance index,local renal volume increase,vas-cular endothelial growth factor(VEGF)and matrix metalloproteinase-9(MMP-9)between the two groups(P＜0.05).LASSO regression analysis showed that there were 6 variables in the diagnosis of nephroblastoma under the optimal penalty coefficient λ,which could make the model perform well and had the least influence factors:mass nature,internal echo,adjacent structures invasion and metastasis,accompanying ipsilateral renal vein thrombosis,VEGF and MMP-9.Logistic regression analysis showed that mass nature,internal echo,adjacent structures inva-sion and metastasis,accompanying ipsilateral renal vein thrombosis,VEGF and MMP-9 were the risk factors for nephroblastoma(P＜0.05).R-language was used to draw the diagnostic model of nephroblastoma,which showed that the C-index was 0.939 and the AUC for diagnosis of nephroblastoma was 0.939.Conclusion:Mass nature,internal echo,adjacent structures invasion and metastasis,accompanying ipsilateral renal vein thrombosis,VEGF and MMP-9 are related to the occurrence of nephroblastoma.The diagnostic model based on ultrasonography and tumor cytokines has a high degree of differentiation,calibration and diagnostic efficiency,which can provide refer-ence for the clinical diagnosis of nephroblastoma.
万方数据
维普
