Application of peripheral blood miR-299 and miR-23a in the diagnosis and prognosis evaluation of PE patients
Objective:To explore the application value of peripheral blood miR-299 and miR-23a in the diagnosis of preeclampsia(PE)patients and their prognostic evaluation.Methods:A total of 84 PE patients who visited Shiy-an People's Hospital from January 2020 to January 2023 were retrospectively selected as the study subjects(observa-tion group),and 73 normal pregnant women were randomly selected as the control group.The expression levels of miR-299 and miR-23a in serum were detected.Multivariate Logistic regression model was applied to analyze the in-fluencing factors of PE in pregnant women.Receiver operating characteristic curve was applied to analyze the diag-nostic value of miR-299 and miR-23a for PE;Kaplan-Meier method was applied to analyze the impact of miR-299 and miR-23a expression levels on pregnancy survival in the observation group.Results:The levels of miR-299 and miR-23a in the serum of the observation group(3.13±0.84,1.94±0.55)were obviously higher than those of the control group(2.34±0.73,1.47±0.43)(P＜0.05).Logistic regression showed miR-299 and miR-23a levels were risk factors for PE development(P＜0.05).The diagnostic results of miR-299 combined with miR-23a were superior to any individual analysis(Zcombination-miR-299=2.067,P=0.038;Zcombination-miR-23a=2.086,P=0.037).The mortality rate of patients with high expression of miR-299 and miR-23a was obviously higher than that of the low ex-pression(P＜0.05).Conclusion:The expression levels of miR-299 and miR-23a in the serum of PE patients are both up-regulated,the combination of the two has certain diagnostic value for PE,and their expression levels are closely related to the prognosis of PE patients.
万方数据
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