Correlation analysis of serum sVCAM-1,ANXA2,CXCL11 expression with disease condition and prognosis in children with bronchopneumonia
Objective:To explore the clinical role of detecting soluble vascular cell adhesion molecule-1(sVCAM-1),annexin A2(ANXA2),and CXC chemokine ligand-11(CXCL11)levels in the disease and prognosis evalua-tion of children with bronchopneumonia.Methods:102 children with bronchopneumonia accepted by our hospital were retrospectively included as the bronchopneumonia group.The Clinical Pulmonary Infection Score(CPIS)was used to evaluate the condition and divided them into a mild group and a severe group.According to the prognosis of the children,they were separated into a good prognosis group and a poor prognosis group;another 106 children who underwent health examinations in our hospital were included as the healthy control group.ELISA method was ap-plied to detect the levels of sVCAM-1,ANXA2,and CXCL11 in serum.Pearson correlation analysis was applied to evaluate the correlation between serum indicators and CPIS,Logistic regression was applied to analyze the influen-cing factors,ROC curve was applied to analyze the diagnostic value of indicators.Results:The serum levels of sV-CAM-1,ANXA2,and CXCL11 in the bronchopneumonia group were greatly higher than those in the healthy control group(all P＜0.05).The serum levels of sVCAM-1,ANXA2,CXCL11,and CPIS in the severe group were great-ly higher than those in the mild group(all P＜0.05).The serum levels of sVCAM-1,ANXA2,CXCL11 in chil-dren with bronchopneumonia were positively correlated with the CPIS(r:0.643,0.526,0.677,all P＜0.05).sVCAM-1(OR=2.478),ANXA2(OR=2.662),and CXCL11(OR=2.407)were influencing factors for the pro-gression of bronchopneumonia in children(all P＜0.05).The AUC of serum sVCAM-1,ANXA2,and CXCL11 levels for diagnosing severe bronchopneumonia was 0.825,0.811,and 0.833,which was greatly lower than the AUC of combined diagnosis,0.971(all P＜0.05).The serum levels of sVCAM-1,ANXA2,CXCL11,and CPIS in poor prognosis group were greatly higher than those in good prognosis group(all P＜0.05).Conclusion:The se-rum levels of sVCAM-1,ANXA2,and CXCL11 in children with bronchopneumonia are related to the severity and prognosis of the disease.The detection of these indicators can assist in clinical evaluation of disease and prognosis of the children.
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