Diagnostic value of TSGF and OSM levels in serum and pleural effusion for malignant pleural effusion
Objective:Exploring the diagnostic value of tumor specific growth factor(TSGF)and oncostatin M(OSM)levels in malignant pleural effusion(MPE).Methods:One hundred and seventy-two patients with exuda-tive pleural effusion(PE)who underwent treatment in our hospital from February 2021 to February 2023 were se-lected as the study subjects,and the patients were divided into the MPE group and the benign pleural effusion(BPE)group according to the results of the examination after admission.General data of patients were collected,and blood was collected to test relevant biochemical indexes;TSGF and OSM levels in serum and PE were detected by enzyme immunoassay;multifactorial Logistic analysis was performed to analyze the influencing factors of the oc-currence of MPE;and ROC curves were performed to analyze the diagnostic value of TSGF and OSM levels on MPE.Results:Lactate dehydrogenase(LDH)and pleural effusion adenosine deaminase(PE ADA)levels in the MPE group compared with those in the BPE group showed statistically significant differences(P＜0.05);TSGF and OSM levels in serum and PE were significantly higher in patients in the MPE group compared with those in the BPE group(P＜0.05);and the results of the multifactorial Logistic analysis showed that LDH,PE ADA,TSGF and OSM levels in serum and PE were all factors influencing the occurrence of MPE(P＜0.05).The area under the curve(AUC)of serum TSGF,OSM,and their combined diagnosis for MPE was 0.798,0.855,and 0.925,respective-ly.The sensitivity and specificity of their combined diagnosis were 88.30％and 84.62％,respectively.The com-bined diagnostic value of the two was higher than that of their individual diagnosis(Zcombination-serum TSGF=4.275,Zcombination-serum OSM=3.297,all P＜0.05).The AUC of PETSGF,PEOSM,and their combination for the diagnosis of MPE was 0.886,0.765,and 0.921,respectively.The sensitivity and specificity of their combined diagnosis were 90.42％and 79.48％,respectively.The combined diagnostic value of PETSGF,PEOSM,and their combination was higher than their individual diagnosis(Zcombination-PETSGF=4.275,Zcombination-PEESM=3.297,all P＜0.05).Conclusion:The levels of TSGF and OSM in the serum and PE of MPE patients are elevated,and the combination of these two indicators has high clinical value in diagnosing MPE.
malignant pleural effusiontumor specific growth factoroncostatin M
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