东南大学学报(医学版)2024，Vol.43Issue(4) ：610-615.DOI:10.3969/j.issn.1671-6264.2024.04.018

肺结核患者血清PGRN、LCN2水平及其与病情严重程度的相关性

Levels of serum PGRN and LCN2 in patients with pulmonary tuberculosis and their correlation with the severity of disease

印薇薇 胡小芳 姜艳萍
东南大学学报(医学版)2024，Vol.43Issue(4) ：610-615.DOI:10.3969/j.issn.1671-6264.2024.04.018
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肺结核患者血清PGRN、LCN2水平及其与病情严重程度的相关性

Levels of serum PGRN and LCN2 in patients with pulmonary tuberculosis and their correlation with the severity of disease

印薇薇 1胡小芳 2姜艳萍2
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作者信息

  • 1. 无锡市第五人民医院呼吸与危重症医学科,江苏无锡 214000
  • 2. 无锡市第五人民医院结核科,江苏无锡 214000
  • 折叠

摘要

目的:探讨肺结核(PTB)患者血清颗粒蛋白前体(PGRN)、脂质运载蛋白2(LCN2)水平及其与病情严重程度的相关性.方法:选取2020年2月至2023年2月于本院就诊的127例肺结核患者,根据病情严重程度将其分为轻症组(n=78)和重症组(n=49),另选取同期体检健康者72例作为对照组.采用酶联免疫吸附法测定各组血清PGRN和LCN2水平;Spearman法分析血清PGRN和LCN2水平与Bandim结核病(TB)评分之间的相关性;多因素Logistic回归分析重症PTB发生的影响因素;绘制受试者工作特征(ROC)曲线分析血清PGRN和LCN2水平对重症PTB的诊断价值.结果:重症组血清PGRN和LCN2水平明显高于轻症组和对照组(P＜0.05);重症组糖尿病史占比,Bandim TB评分,IL-10、IFN-γ、PCT、CRP水平明显高于轻症组(P＜0.05);血清PGRN和LCN2水平与Bandim TB评分均呈正相关(rs值分别为0.428、0.420,均P＜0.001);PGRN(OR=1.576,95％CI:1.112～2.234)和 LCN2(OR=2.163,95％CI:1.320～3.545)为重症 PTB发生的危险因素(P＜0.05);血清PGRN和LCN2水平联合诊断重症PTB的曲线下面积(AUC)为0.943,敏感度为91.84％,二者联合优于各自单独诊断(Z二者联合-PGRN=2.327,P=0.020;Z二者联合-LCN2=2.061,P=0.039).结论:PTB患者血清PGRN和LCN2水平与Bandim TB评分呈正相关,二者血清水平与患者病情严重程度密切相关.

Abstract

Objective:To investigate the levels of progranulin(PGRN)and lipocalin-2(LCN2)in the serum of patients with pulmonary tuberculosis(PTB)and their correlation with the severity of the disease.Methods:From February 2020 to February 2023,127 pulmonary tuberculosis patients who visited our hospital were regarded as the study subjects.They were separated into mild disease group(n=78)and severe disease group(n=49)based on the severity of the disease.Additionally,72 healthy individuals who underwent physical examination were regarded as the control group.Enzyme-linked immunosorbent assay(ELISA)was applied to determine the levels of serum PGRN and LCN2 in each group;Spearman method was applied to analyze the correlation between serum PGRN and LCN2 levels and Bandim TB score;multivariate Logistic regression was applied to analyze the influencing factors of severe PTB occurrence;receiver operating characteristic(ROC)curve was plotted to analyze the diagnostic value of serum PGRN and LCN2 levels for severe PTB.Results:The serum levels of PGRN and LCN2 in the severe group were obviously higher than those in the mild group and the control group(P＜0.05);the proportion of diabetes his-tory,Bandim TB score,IL-10,IFN-γ,PCT,CRP levels in severe group were obviously higher than those in mild group(P＜0.05);the levels of serum PGRN and LCN2 were positively correlated with Bandim TB score(rs=0.428,0.420,allP＜0.001);PGRN(OR=1.576,95％CI=1.112-2.234)and LCN2(OR=2.163,95％CI=1.320-3.545)were risk factors for the occurrence of severe PTB(P＜0.05);the area under the curve(AUC)of the combination of serum PGRN and LCN2 levels for diagnosing severe PTB was 0.943,with a sensitivity of 91.84％,the combination of the two was superior to individual diagnosis(Zcombination-PGRN=2.327,P=0.020;Zcombination-LCN2=2.061,P=0.039).Conclusion:The serum levels of PGRN and LCN2 in PTB patients are posi-tively correlated with Bandim TB score,and their serum levels are closely related to the severity of disease.

关键词

颗粒蛋白前体/脂质运载蛋白2/肺结核/病情严重程度

Key words

progranulin/lipocalin-2/pulmonary tuberculosis/severity of disease

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出版年

2024
东南大学学报(医学版)
东南大学

东南大学学报(医学版)

CSTPCD
影响因子：1.374
ISSN：1671-6264
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