Correlation between serum levels of SCC-Ag,CA50,CYFRA21-1 with clinical staging and prognosis in patients with epithelial ovarian cancer
Objective:To investigate the correlation between serum levels of squamous cell carcinoma antigen(SCC-Ag),carbohydrate antigen 50(CA50),cytokeratin 19 fragment(CYFRA21-1)with clinical staging and prognosis in patients with epithelial ovarian cance.Methods:From June 2018 to October 2020,76 EOC patients accepted by our hospital were included as the study subjects(EOC group),including 12 cases of federation interna-tional of gynecology and obstetrics(FIGO)stage Ⅰ,24 cases of stage Ⅱ,19 cases of stage Ⅲ,and 21 cases of stage Ⅳ.Another 80 cases of healthy people with physical examination were selected as the control group.Chemi-luminescence immunoassay was applied to determine the levels of SCC-Ag,CA50,and CYFRA21-1.Follow up for 3 years,and the patients were categorized into a poor prognosis group of 30 cases and a good prognosis group of 46 cases.Spearman correlation was applied to analyze the correlation between serum levels of SCC-Ag,CA50,CY-FRA21-1 and clinical staging.Receiver operating characteristic(ROC)curve was applied to analyze the predictive value of serum SCC-Ag,CA50,and CYFRA21-1 levels for poor prognosis in EOC patients.Relationship between serum SCC-Ag,CA50,and CYFRA21-1 expression and prognosis of EOC patients were analyzed by Kaplan-Meier survival curves.Multivariate Cox regression was applied to analyze the influencing factors of poor prognosis in EOC patients.Results:Compared with the control group,the serum SCC-Ag,CA50,and CYFRA21-1 levels in the EOC group were obviously increased(P＜0.001).With the increase of FIGO staging in EOC patients,the levels of SCC-Ag,CA50,and CYFRA21-1 obviously increased in sequence(P＜0.05).The serum levels of SCC-Ag,CA50,and CYFRA21-1 in EOC patients were positively correlated with FIGO staging(P＜0.05).The proportion of patients with FIGO stages Ⅲ-Ⅳ and the levels of serum SCC-Ag,CA50,CYFRA21-1 in the poor prognosis group were higher than those in the good prognosis group(P＜0.001).ROC curve results showed that the AUC of poor prognosis in EOC patients predicted by serum SCC-Ag,CA50,CYFRA21-1 levels alone and in combination was 0.868,0.857,0.850,and 0.954,respectively,and the combined prediction of the three was better than the single diagnosis(Z=2.214,2.826,2.831,P＜0.05).The 3-year survival rates of patients in the SCC-Ag,CA50,CYFRA21-1 high-expression groups were lower than those in the SCC-Ag,CA50,CYFRA21-1 low-expres-sion groups,respectively(Log-rank x2=21.494,21.449,16.727,P＜0.001).The results of multivariate Cox re-gression analysis showed that SCC-Ag,CA50,and CYFRA21-1 were risk factors for poor prognosis in EOC patients(P＜0.05).Conclusion:Elevated levels of serum SCC-Ag,CA50,and CYFRA21-1 in EOC patients are closely related to clinical staging and prognosis.
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