Expression levels of PTPN6 and PAX8 in lung cancer tissue and their relationship with prognosis
Objective:To explore the expression levels of protein tyrosine phosphatase non-receptor type 6(PTPN6)and paired box gene 8(PAX8)in lung cancer tissue and their relationship with prognosis.Methods:A total of 86 lung cancer patients admitted to our hospital from January 2019 to January 2021 were collected,and their cancer tissues and adjacent tissues were collected during surgery.The mRNA expression of PTPN6 and PAX8 in the two tissues was detected by real-time fluorescence quantitative PCR(qRT-PCR),and the protein expression of PT-PN6 and PAX8 in the two tissues was detected by immunohistochemistry.Results:Significantly reduced levels of PTPN6 mRNA expression were observed in lung cancer tissues compared to the adjacent tissues(P＜0.05),while a marked increase was noted for PAX8 mRNA expression in the same comparison(P＜0.05).The 3-year survival rate of patients with PTPN6 protein positive expression in lung cancer tissue was higher than that of patients with negative expression(P＜0.05).The 3-year survival rate of patients with positive expression of PAX8 protein in lung cancer tissue was lower than that of patients with negative expression(P＜0.05).Lymph node metastasis,tumor diameter＞3.0 cm,low differentiation,TNM stage Ⅲ-Ⅳ,negative expression of PTPN6,and positive ex-pression of PAX8 were risk factors affecting the prognosis of lung cancer patients(P＜0.05).Conclusion:The ex-pression level of PTPN6 decreases in lung cancer tissue,while the expression level of PAX8 increases,and can be used as indicators for evaluating prognosis.
lung cancerprotein tyrosine phosphatase non-receptor type 6paired box gene 8prognosis
万方数据
维普
