Value of trans vaginal color Doppler sonography combined with serum miR-1266 and miR-203a-3p in the differential diagnosis of cervical precancerous lesions and cervical cancer
Objective:To explore the differential diagnostic value of transvaginal color Doppler sonography(TVCDS)combined with serum microRNA-1266(miR-1266)and microRNA-203a-3p(miR-203a-3p)in cervical cancer and precancerous lesions.Methods:From August 2022 to October 2023,97 cervical cancer patients who admitted to our hospital were collected as the cervical cancer group,and another 99 patients with cervical precan-cerous lesions were regarded as the precancerous lesion group.The consistency between TVCDS and the combina-tion of miR-1266 and miR-203a-3p in cervical biopsy diagnosis of cervical cancer was tested using Kappa test;the influencing factors of cervical cancer occurrence were analyzed using multivariate Logistic regression analysis;the diagnostic value of TVCDS combined with serum miR-1266 and miR-203a-3p levels for cervical cancer was ana-lyzed using receiver operating characteristic(ROC)curve.Results:The levels of squamous cell carcinoma antigen(SCC),carcinoembryonic antigen(CEA),carbohydrate antigen(CA)199,CA125,and the proportion of parturition frequency＞3 times in the cervical cancer group were higher than those in the precancerous lesion group(t/x2=10.081,9.963,8.149,9.637,4.582,P＜0.05).The serum miR-1266 level in the cervical cancer group was obviously higher than that in the precancerous lesion group(t=8.293,P＜0.05),and the serum miR-203a-3p level was lower than that in the precancerous lesion group(t=9.713,P＜0.05).The consistency between the combination of TVCDS,serum miR-1266 and miR-203a-3p and cervical biopsy(Kappa value=0.766)was higher than that of TVCDS diagnosis alone(Kappa value=0.704).Multivariate Logistic analysis showed that SCC,CEA,CA199,CA125,miR-1266,and miR-203a-3p were all influencing factors for the occurrence of cervical cancer(P＜0.05).ROC curve analysis showed that the sensitivity(94.85％)of TVCDS combined with serum miR-1266 and miR-203a-3p was better than the single diagnosis of the three,and the diagnostic accuracy(88.27％)was bet-ter than the single diagnosis of serum miR-1266 and miR-203a-3p.Conclusion:Cervical cancer patients have higher serum miR-1266 level and lower miR-203a-3p level.TVCDS combined with serum miR-1266 and miR-203 a-3 p has higher diagnostic value for cervical cancer.
cervical cancerprecancerous lesionstransvaginal color Doppler sonographymicroRNA-1266mi-cro RNA-203a-3p
万方数据
维普
