The correlation between amniotic fluid single nucleotide polymorphism microarray chips,TORCH detection results and critical ventricular widening in fetuses and its pregnancy outcomes
Objective:To analyze the correlation between amniotic fluid single nucleotide polymorphism microar-ray(SNP-Array)and five aspects of eugenics(TORCH)detection results and critical ventriculomegaly(VM)fetuses and its pregnancy outcomes.Methods:Eighty pregnant women who underwent prenatal examinations and diagnosed with fetal critical VM through ultrasound examination in our hospital from October 2014 to October 2021 were select-ed as the study object.All pregnant women underwent amniotic fluid SNP-Array and TORCH testing.The relation-ship between SNP-Array,TORCH detection results and fetal critical VM was analyzed by Pearson correlation analy-sis.The pregnancy outcomes was observed,and the relationship between SNP-Array,TORCH detection results and adverse pregnancy outcomes of critical VM fetuses was analyzed by conditional Logistic regression analysis.Re-sults:The SNP-Array detection results of the 80 critical VM fetuses showed that the detection rate of fetal pathogen-ic chromosomal abnormalities was 11.25％(9/80),including 5 cases of chromosomal microdeletions and 4 cases of chromosomal microduplications.The detection rate of possible pathogenic chromosomal abnormalities was 3.75％(3/80),with 2 cases of chromosomal microdeletions and 1 case of chromosomal microduplication.The detection rate of chromosomal abnormalities with unclear significance was 1.25％(1/80),indicating chromosomal micro du-plication.The detection rate of chromosomal abnormalities with unclear significance was 1.25％(1/80),indicating chromosomal micro duplication.The total positive rate of TORCH-immunoglobulin M(IgM)antibodies was 15.00％(12/80),with toxoplasma gondii(TOX)-IgM,rubella virus(RV)-IgM,cytomegalovirus(CMV)-IgM and herpes simplex virus(HSV)-IgM positive rates of 5.00％(4/80),1.25％(1/80),5.00％(4/80)and 3.75％(3/80)respectively.According to Pearson correlation analysis,SNP-Array detection of pathogenic chromosomal abnormali-ties and TORCH-IgM antibody positivity were positively correlated with fetal critical VM(P＜0.05).The results of Logistic regression analysis showed that abnormal SNP-Array detection and positive TORCH detection were risk fac-tors for adverse pregnancy outcomes in critical VM fetuses(P＜0.05).Conclusion:Critical VM fetal amniotic flu-id has abnormal SNP-Array detection and a high positive rate of TORCH-IgM antibody detection,and the detection of pathogenic chromosomal abnormalities by SNP-Array and TORCH-IgM antibody positivity are related to the oc-currence of fetal critical VM and adverse pregnancy outcomes.
critical ventricular wideningsingle nucleotide polymorphism arrayfive aspects of eugenics
万方数据
维普
