Relationship between changes of serum TGF-β1 and SDF-1 levels with prognosis in patients with myelodysplastic syndrome
Objective:To explore the relationship between changes of serum transforming growth factor-β1(TGF-β1)and stromal cell derived factor 1(SDF-1)expression levels with prognosis in patients with myelodysplastic syn-drome(MDS).Methods:92 MDS patients diagnosed and treated in our hospital were selected as the research group,and a control group of 92 volunteers who underwent health checkups were selected(January 2021 to June 2023).Enzyme linked immunosorbent assay(ELISA)was applied to compare the changes of serum levels of TGF-β1 and SDF-1 between the research group and the control group.The multivariate Logistic regression analysis was used to investigate the causes of poor prognosis;the prognostic value of TGF-β1 and SDF-1 was evaluated by re-ceiver operating characteristic(ROC)curve.Results:Compared with the control group,the expression of serum TGF-β 1 level in research group was significantly down-regulated,and the expression of SDF-1 level was signifi-cantly up-regulated(all P＜0.05).As the IPSS score level increased,the level of TGF-β1 showed a obvious down-ward trend,while the level of SDF-1 showed a obvious upward trend(P＜0.05).The level of TGF-β1 in the poor prognosis group was obviously lower than that in the good prognosis group,and the level of SDF-1 was obviously higher than that in the good prognosis group(all P＜0.05).Multivariate Logistic regression analysis showed that low TGF-β1 level and high SDF-1 level were risk factors for poor prognosis in MDS patients(P＜0.05).According to the ROC curve,the AUC predicted by serum TGF-β1 and SDF-1 for predicting the prognosis of MDS patients were 0.754 and 0.798,respectively.The AUC predicted by the combination of the two was obviously higher than that predicted by TGF-β1 and SDF-1 alone(ZTGF-β1=2.733,ZSDF-1=2.162,all P＜0.05).Conclusion:The ex-pression level of serum TGF-β1 decreases in MDS patients,while the expression level of SDF-1 increases.Both are factors that affect the prognosis of MDS patients.The combination of the expression levels of TGF-β1 and SDF-1 have high value in predicting the prognosis of MDS patients.
万方数据
维普
