The impact of single nucleotide polymorphisms on postoperative pain in gynecological laparoscopic surgery and gene interactions analysis
Objective:To investigate the underlying factors,including general characteristics,single nucleotide polymorphisms(SNPs),and gene interactions,influencing variances in postoperative pain following gynecological laparoscopic surgery.Methods:A cohort comprising 206 patients undergoing elective laparoscopic gynecological procedures at the Chongqing Health Center for Women and Children between August and December 2022 was en-rolled.Prior to surgery,demographic information along with pain sensitivity questionnaire(PSQ)and pain cata-strophizing scale(PCS)scores were obtained.Peripheral blood samples were collected for pain-related gene analy-sis.Standard induction anesthesia was administered,followed by the laparoscopic procedure.After awakening,pain was assessed using the visual analog scale(VAS).VAS score≥ 3 was considered the pain group,while VAS score＜3 was the control group.Logistic regression analysis was conducted to identify preoperative factors associated with postoperative pain.Additionally,multifactor dimensionality reduction(MDR)analysis was employed to explore gene-gene interactions related to pain.Results:Spice preference and preoperative PCS scores were significantly as-sociated with postoperative pain.No significant correlation was found between individual SNPs and postoperative pain.MDR analysis suggested that the best interaction model included CYP450 3A41G rs2242480 and OPRM A118G rs1799971.Conclusion:Spice preference and elevated preoperative PCS scores emerged as risk factors for postoperative pain in gynecological laparoscopic surgery.Moreover,there is an interaction between CYP450 3A41G rs2242480 and OPRM A118G rs1799971 in influencing postoperative pain.
万方数据
维普
