Expression and clinical significance of TUFT1 and TRPM7 in cervical cancer tissue
Objective:To investigate the expression and clinical significance of Tuftelin-1(TUFT1)and transient receptor potential melastatin 7(TRPM7)in cervical cancer tissue.Methods:Intraoperative cervical cancer tissue specimens and adjacent tissue specimens of 110 patients with cervical cancer who were hospitalized for surgery dur-ing January 2019 to January 2021 were collected,and the expressions of TUFT1 and TRPM7 were detected by im-munohistochemistry.Kaplan-Meier method was used to analyze the relationship of TUFT1 and TRPM7 expression level with prognosis.The correlation of TUFT1 and TRPM7 expression was analyzed by Spearman correlation analy-sis.Cox regression was used to analyze the influencing factors of prognosis.Results:The positive rates of TUFT1 and TRPM7 in cervical cancer tissues increased compared to adjacent tissues(P＜0.05).The positive expression rates of TUFT1 and TRPM7 of patients with low differentiation,tumor diameter≥4 cm,and International Federation of Obstetrics and Gynecology(FIGO)stage Ⅱ+Ⅲ were higher than those of patients with medium to high differen-tiation,tumor diameter＜4 cm,and FIGO stage Ⅰ(P＜0.05).The expression levels of TUFT 1 and TRPM7 were directly correlated(r=0.445,P＜0.05).The 3-year survival rate of TUFT1 positive expression patients(53.66％,44/82)was lower than that of TUFT1 negative expression patients(78.57％,22/28)(x2=4.679,P=0.031).The 3-year survival rate of TRPM7 positive expression patients(40.98％,25/61)was lower than that of TRPM7 negative expression patients(83.67％,41/49)(x2=19.290,P＜0.001).TUFT1 and TRPM7 were risk factors for mortality in cervical cancer patients(P＜0.05).Conclusion:TUFT1 and TRPM7 are highly expressed in cervical cancer tissue,and they are closely related to the 3-year prognosis of patients,which may become impor-tant biological indicators for prognosis judgment.
万方数据
维普
