Analysis of the association between triglyceride-glucose index and non-target lesions progression after coronary stenting based on propensity score matching
Objective:To investigate the relationship between the triglyceride-glucose(TyG)index and the pro-gression of non-target lesions(NTL)after coronary stenting.Methods:A total of 679 patients who underwent coro-nary angiography(CAG)and stenting at the Affiliated Taizhou People's Hospital of Nanjing Medical University from January 2019 to December 2022 were selected.These patients were readmitted for follow-up CAG 9-12 months post-procedure.The presence of NTL progression was assessed based on quantitative CAG results from the two hospitali-zations.Patients were divided into an NTL progression group and a non-progression group(control group).A pro-pensity score matching(PSM)method with a 1∶1 ratio was used to construct a matched dataset to analyze the asso-ciation between TyG index and NTL progression.The predictive value of TyG index for NTL progression was evalua-ted using receiver operating characteristic(ROC)curves.Results:After PSM,significant differences in TyG index and TyG quartile distributions were observed between the NTL progression group and the control group(both P＜0.05).Logistic regression analysis revealed that TyG index was an independent risk factor for NTL progression.The risk of NTL progression was doubled in the highest TyG quartile compared to the lowest TyG index quartile(OR=2.05,95％CI:1.03-4.45,P=0.038).Restricted cubic spline curve showed,as TyG index increased,the risk of NTL progression also increased,showing a dose-response relationship.The area under the ROC curve for TyG in-dex predicting NTL progression was 0.607(95％CI:0.554-0.660).Conclusion:TyG index is an independent risk factor for NTL progression after coronary stenting and has predictive value for NTL progression.
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