Correlation analysis of serum SCUBE1 and CTRP5 levels with disease progression and prognosis in patients with pulmonary heart disease
Objective:To investigate the correlation between the levels of serum signal peptide-CUB-epidermal growth factor-like domain-containing protein 1(SCUBE1),complement C1q tumor necrosis factor related protein 5(CTRP5)and progression,prognosis of disease.Methods:160 patients with pulmonary heart disease who visited our hospital from January 2020 to January 2023 were selected.According to the severity of the patient's condition,they were divided into a compensated group(n=80)and a decompensated group(n=80);according to the patient's prognosis,they were separated into a poor prognosis group(n=55)and a good prognosis group(n=105).Another 160 healthy individuals who came to our hospital for physical examination were regarded as the control group.The SCUBE1 and CTRP5 expression levels in serum of subjects were detected by ELISA method.The differ-ences of serum SCUBE1 and CTRP5 expression levels were compared and analyzed among different groups.Logistic regression was applied to analyze the influencing factors of poor prognosis in patients with pulmonary heart disease,and ROC curve was applied to analyze the predictive value of SCUBE1 and CTRP5 for poor prognosis in patients with pulmonary heart disease.Results:The serum levels of SCUBE1 and CTRP5 in the pulmonary heart disease group were obviously higher than those in the control group(P＜0.05);the serum levels of SCUBE1 and CTRP5 in the compensated group were obviously lower than those in the decompensated group(P＜0.05);the proportion of smoking history,and the levels of serum SCUBE1 and CTRP5 in the poor prognosis group were obviously higher than those in the good prognosis group(P＜0.05);smoking history,serum SCUBE1 and CTRP5 were risk factors for poor prognosis in patients with pulmonary heart disease(P＜0.05);the prediction of combined serum SCUBE1 and CTRP5 for poor prognosis in patients with pulmonary heart disease was obviously more effective than the two a-lone prediction(ZSCUBE1-co)mbinedprediction=3.765,P＜0.001;ZCTRP5-combinedprediction=2.067,P=0.039).Conclusion:The levels of serum SCUBE1 and CTRP5 in patients with pulmonary heart disease are closely related to disease pro-gression and prognosis,and the combination of the two has high predictive value for patient prognosis.
pulmonary heart diseaseserum signal peptide-CUB-epidermal growth factor-like domain-containing protein 1complement C1q tumor necrosis factor related protein 5progression of diseaseprognosiscorrelation
万方数据
维普
