Analysis of serum CTRP3 and CTRP9 level changes and the relationships between them and OP in patients with rheumatoid arthritis
Objective:To observe the changes in serum levels of C1q necrosis factor related protein(CTRP)3 and CTRP9 in patients with rheumatoid arthritis(RA),and to analyze their relationships with osteoporosis(OP).Methods:185 RA patients admitted to the hospital from January 2019 to December 2022 were enrolled,and en-zyme linked immunosorbent assay was used to detect serum levels of CTRP3,CTRP9,N-terminal peptide of type Ⅰprocollagen(PⅠ NP),bone alkaline phosphatase(BALP),osteocalcin(BGP),and 25 hydroxyvitamin D3[25-(OH)-D3]and dual energy X-ray was used to detect bone mineral density(BMD)in the lumbar spine and femoral neck.Pearson method was used to analyze the relationships between serum CTRP3,CTRP9 and bone metabolism,BMD.Patients were followed up and divided into OP group and non OP group based on the follow-up results.The general informations and serum levels of CTRP3 and CTRP9 were compared between two groups,and Logistic re-gression analysis was conducted on the influencing factors of OP.Results:Serum CTRP3 and CTRP9 were positive-ly correlated with BALP,BGP,25-(OH)-D3,lumbar BMD,and femoral neck BMD(r:0.559,0.524,0.510,0.552,0.578,P＜0.05;r:0.531,0.516,0.498,0.527,0.539,P＜0.05),while they were negatively corre-lated with PⅠNP(r:-0.458,-0.563,P＜0.05).The incidence of OP was 29.82％(51/171).The serum levels of CTRP3 and CTRP9 in the OP group were lower than those in the non OP group(P＜0.05).Female[odds ratio(OR)=1.581,95％confidence interval(95％CI):1.031-2.424],age(OR=1.738,95％CI:1.130-2.676),RA course(OR=1.766,95％CI:1.164-2.682),rheumatoid arthritis disease activity(DAS-28)score(OR=1.844,95％CI:1.234-2.756),serum CTRP3(OR=0.586,95％CI:0.381-0.902),serum CTRP9(OR=0.647,95％CI:0.423-0.987),the maximum dose of glucocorticoids(OR=1.956,95％CI:1.141-3.353),active vitamin D supplementation therapy(OR=0.636,95％CI:0.426-0.948),and calcium supple-mentation therapy(OR=0.624,95％CI:0.395-0.986)were all influencing factors for OP(P＜0.05).Conclusion:The serum levels of CTRP3 and CTRP9 in RA patients are related to bone metabolism and BMD,and the two are influencing factors for OP,including female gender,age,RA course,DAS-28 score,maximum dose of glucocorticoids,active vitamin D supplementation therapy,and calcium supplementation therapy.
rheumatoid arthritisC1q necrosis factor related protein 3C1q necrosis factor related protein 9os-teoporosis
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