Analysis of MMP-2 and SPA expression levels in alveolar lavage fluid of elderly patients with severe pneumonia and their predictive value for survival status
Objective:To explore the expression levels of matrix metalloproteinase-2(MMP-2)and pulmonary surfactant-associated protein A(SPA)in alveolar lavage fluid of elderly patients with severe pneumonia,and their predictive value for survival status.Methods:A total of 98 elderly patients with severe pneumonia in our hospital from November 2021 to October 2023 were regarded as the severe group.They were separated into a death group(34 cases)and a survival group(64 cases)based on their 30-day survival status after admission.95 patients with mild pulmonary infection who were admitted for treatment were regarded as the control group.The levels of MMP-2 and SPA in alveolar lavage fluid were compared between the severe group and the control group,and the clinical data and levels of MMP-2 and SPA in alveolar lavage fluid were compared between the survival group and the death group;Cox regression was applied to analyze the influencing factors of patient survival status;receiver operating characteristic(ROC)curve was applied to analyze the predictive values of MMP-2 and SPA levels in alveolar lavage fluid on survival status;Kaplan-Meier curve was applied to analyze the relationship between MMP-2,SPA expres-sion levels and patient survival rate.Results:The level of MMP-2 in the alveolar lavage fluid of the severe group was higher than that of the control group,and the SPA level was lower than that of the control group(P＜0.05);the oxygenation index of patients in the survival group was higher than that in the death group(P＜0.05);the MMP-2 level in the alveolar lavage fluid of the survival group was lower than that of the death group,and the SPA level was higher than that of the death group(P＜0.05);MMP-2 in alveolar lavage fluid was a risk factor for death in elderly patients with severe pneumonia,while SPA was a protective factor(P＜0.05);the efficacy of MMP-2 combined with SPA in predicting the survival of elderly patients with severe pneumonia in alveolar lavage fluid was higher than that predicted by various indicators alone(Zcombination-MMP-2=4.158,P＜0.001;Zcombination-SPA=2.060,P=0.039);the survival rate of the MMP-2 low expression group was obviously higher than that of the MMP-2 high expression group(P＜0.05),and the survival rate of the SPA high expression group was obviously higher than that of the SPA low expression group(P＜0.05).Conclusion:MMP-2 level in the alveolar lavage fluid of elderly pa-tients with severe pneumonia increases,while SPA level decreases.The efficacy of MMP-2 combined with SPA in predicting the survival of elderly patients with severe pneumonia is higher than that of a single indicator alone.
severe pneumoniaalveolar lavage fluidmatrix metalloproteinase 2pulmonary surfactant-associated protein Asurvivalpredictive value
万方数据
维普
