首页|Biological functions and potential implications of circular RNAs
Biological functions and potential implications of circular RNAs
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Circular RNAs(circRNAs)are characterized by a covalent closed-loop structure with an absence of both 5'cap structure and 3'polyadenylated tail.Numerous studies have found that circRNAs play an important role in various diseases and have a variety of biological regulatory mechanisms,including acting as microRNA sponges,interacting with proteins,modulating the expression of related genes and translating into peptides or proteins.CircRNAs have also been used as biomarkers for a number of diseases,which could improve clinical practice.This review summarizes the most recent advances in biogenesis and knowledge of the biological functions of circRNAs as well as the related bioinformatics databases.We specifically describe developments in understanding of circRNA functions in the field of environmental exposure-induced diseases.Finally,we focus on potential clinical implications of circRNAs to facilitate their clinical transformation into disease treatment.
Department of Genetic Toxicology,The Key Laboratory of Modern Toxicology of Ministry of Education,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China
Department of Environmental Genomics,Jiangsu Key Laboratory of Cancer Biomarkers,Prevention and Treatment,Collaborative Innovation Center for Cancer Personalized Medicine,Nanjing Medical University,Nanjing,Jiangsu 211166,China
National Natural Science Foundation of ChinaPriority Academic Program Development of Jiangsu Higher Education Institutions
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