Gut microbiota links with cognitive impairment in amyotrophic lateral sclerosis:A multi-omics study

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外文摘要：Recently,cognitive impairments(CI)and behavioral abnormalities in patients with amyotrophic lateral sclerosis(ALS)have been reported.However,the underlying mechanisms have been poorly understood.In the current study,we explored the role of gut microbiota in CI of ALS patients.We collected fecal samples from 35 ALS patients and 35 healthy controls.The cognitive function of the ALS patients was evaluated using the Edinburgh Cognitive and Behavioral ALS Screen.We analyzed these samples by using 16S rRNA gene sequencing as well as both untargeted and targeted(bile acids)metabolite mapping between patients with CI and patients with normal cognition(CN).We found altered gut microbial communities and a lower ratio of Firmicutes/Bacteroidetes in the CI group,compared with the CN group.In addition,the untargeted metabolite mapping revealed that 26 and 17 metabolites significantly increased and decreased,respectively,in the CI group,compared with the CN group.These metabolites were mapped to the metabolic pathways associated with bile acids.We further found that cholic acid and chenodeoxycholic acid were significantly lower in the CI group than in the CN group.In conclusion,we found that the gut microbiota and its metabolome profile differed between ALS patients with and without CI and that the altered bile acid profile in fecal samples was significantly associated with CI in ALS patients.These results need to be replicated in larger studies in the future.

外文关键词：

amyotrophic lateral sclerosiscognitive declinegut microbiotafecal metabolitesbile acids

作者：

Zhenxiang Gong、Li Ba、Jiahui Tang、Yuan Yang、Zehui Li、Mao Liu、Chun Yang、Fengfei Ding、Min Zhang

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作者单位：

Department of Neurology and Psychiatry,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China

Department of Neurology,SUNY Downstate Medical Center,NY 11226,USA

Department of Anesthesiology and Perioperative Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China

Department of Pharmacology,School of Basic Medical Sciences,Fudan University,Shanghai 200032,China

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基金：

National Key Research and Development Program of ChinaNational Key Research and Development Program of Chinaclinical research project of the Bethune Charitable Foundation

项目编号：

2018YFE01189002021YFC2502200

出版年：

2023

生物医学研究杂志(英文版)

南京医科大学

生物医学研究杂志(英文版)

CSCD北大核心

影响因子：0.794

ISSN：1674-8301

年,卷(期)：2023.37(2)

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